Efficacy of Vitamin C Treatment to Aid the Healing of Foot Ulcers in People With Diabetes: A Randomised, Placebo-Controlled Double-Blind Trial: The FOOT-C Study Protocol.

Diabetic foot ulcers are a serious and common complication of diabetes that can lead to infection and even amputation if not treated properly. Current treatments focus on wound care, infection control, and offloading, but there is growing interest in whether vitamin C, an antioxidant, can speed up healing. This study protocol describes a randomized, placebo-controlled double-blind trial that will test the efficacy of vitamin C supplementation in aiding foot ulcer healing in people with diabetes. The trial will recruit 200 participants and follow them for 24 weeks, measuring the reduction in ulcer area and time to complete healing. The researchers expect that vitamin C will significantly reduce ulcer size and improve healing rates, with fewer adverse events compared to placebo. If proven effective, this could offer a simple, low-cost addition to standard DFU care. However, this is a protocol paper, so the results are not yet available, and the true benefits remain uncertain until the trial is completed and published.